IV Cancer Therapies: New Study Suggests Avoiding Mixing Vitamin C and Glutathione
While both intravenous Vitamin C (ascorbic acid, or AA) and Glutathione (GSH) are popular treatments for cancer patients and often co-administered, a recent study (Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models) has shown that while each may be beneficial independently, they may not be effective in combination.
However, is this a flawed study?
When looking at the in vivo dosages of the GSH given to the mice in the study, the relative dosage if given to a human would be ridiculously high. The dosage if given to the average size human translates to approximately 50-60 grams, which is about 50-60 times what would be considered a normal therapeutic dose of glutathione.
The intravenous administration of Vitamin C is a popular form of cancer and illness treatment as there are no side effects. When treating cancer patients, Vitamin C produces hydrogen peroxide and results in targeted neoplastic cell death, which provides patients with safe pro-oxidative therapy. However there are now also other documented benefits of IVC for cancer patients not captured by this study such as the positive effect to immune regulation that IVC provides. *please contact the clinic if you would like a list of these studies.
GSH intravenous studies aren’t as established, but increased attention is being given to the combination as both are often used in conjunction with each other, both orally and intravenously.
Glutathione is often used in combination with other treatment therapies as it is important in drug metabolism, antioxidant defence, immunology, nutrient metabolism and regulation of cellular events. GSH has a powerful role in cellular protection and is implicated in cancer prevention.
However, just as Vitamin C reacts differently in our body when taken orally versus intravenously, dosage obviously matters. It is interesting to note that while the effects vitamin C had on the tumours in the mouse trial was better in the IVC only group, the mice that also received the GSH with the IVC had a higher rate of survival!!
While there seems to be an antagonism between as vitamin C is a pro-oxidant and GSH is an antioxidant – both are REDUCING agents. They both donate an electron. And they recycle each other in the human body via enzymes.
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